Article

Discovery of LILRA7 as a novel immune receptor reintroduced into humans by archaic introgression

2026-04-16

Abstract excerpt

<title>Abstract</title> <p> The leukocyte receptor complex (LRC) is one of the most polymorphic regions in the human genome and encodes multigene families of innate immune receptors, including leukocyte immunoglobulin-like receptors (LILRs). However, high sequence similarity among LRC genes has hindered comprehensive characterization of this region. Here we identify a previously unrecognized 11.3‑kb insertion lo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6167ba6d-a105-563b-80c2-331c89b4ee8f
DOI: 10.21203/rs.3.rs-9135254/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovery of LILRA7 as a novel immune receptor reintroduced into humans by archaic introgressionDOI 10.21203/rs.3.rs-9135254/v1Read

Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations.Semantic proximity Read

Adaptive variation in human toll-like receptors is contributed by introgression from both Neandertals and DenisovansSemantic proximity Read

Genesis of the ILT/LIR/MIR clusters within the human leukocyte receptor complex.Semantic proximity Read

LILRB1 and LILRB2 genomics and transcriptomics in macaque and baboon species: polymorphism, diversification, and extensive alternative splicing.Semantic proximity Read

Introgression of Neandertal- and Denisovan-like Haplotypes Contributes to Adaptive Variation in Human Toll-like Receptors.Semantic proximity Read

The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotationSemantic proximity Read

The shaping of modern human immune systems by multiregional admixture with archaic humans.Semantic proximity Read

Surveillance of cell and tissue perturbation by receptors in the LRC.Semantic proximity Read

Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes.Semantic proximity Read

Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans.Semantic proximity Read

Copy number and nucleotide variation of the LILR family of myelomonocytic cell activating and inhibitory receptors.Semantic proximity Read

Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair.Semantic proximity Read