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Article

Archaic Introgression Shapes Genetic Variation at Loci Associated With DNA Virus Load in Modern Humans.

Genome biology and evolution - 1 May 2026

Rajpara Rutvi, Polishchuk Sofiia Stefaniia, Yermakovich Danat, Dannemann Michael

Abstract excerpt

Archaic introgression has shaped the modern human immune system, particularly components involved in RNA virus responses. In contrast, its contribution to DNA virus defense remains poorly understood. Here, we investigate the contribution of Neandertal- and Denisovan-introgressed haplotypes to viral load of five common DNA viruses in UK Biobank samples, using genome-wide association summary statistics. We...

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Source

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Identifiers

PMID: 42049271
DOI: 10.1093/gbe/evag110
PMCID: PMC13179500

Genes

ALOX15
ARRB2
GSDMB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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