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Immune context unmasks regulatory effects of Neanderthal and Denisovan introgression

2026-06-01

Abstract excerpt

Neanderthal and Denisovan introgression have left a pervasive footprint in the human genome, yet its regulatory consequences remain poorly understood. Here we use a massively parallel reporter assay to characterize the cis-regulatory activity of 4,161 high-frequency introgressed variants across respiratory (A549), hepatic (HepG2), and hematopoietic (K562) cells exposed to immune and infectious stimuli. We find tha...

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Identifiers and source

Literature Corpus work
8598af91-8c46-5f98-ab17-2b34e0ab54cf
DOI
10.64898/2026.05.29.727880
Open publication

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Immune context unmasks regulatory effects of Neanderthal and Denisovan introgressionDOI 10.64898/2026.05.29.727880
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