Article
Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes.
American journal of human genetics - 7 Jan 2016
Deschamps Matthieu, Laval Guillaume, Fagny Maud, Itan Yuval, Abel Laurent, Casanova Jean-Laurent, Patin Etienne, Quintana-Murci Lluis
Abstract excerpt
Human genes governing innate immunity provide a valuable tool for the study of the selective pressure imposed by microorganisms on host genomes. A comprehensive, genome-wide study of how selective constraints and adaptations have driven the evolution of innate immunity genes is missing. Using full-genome sequence variation from the 1000 Genomes Project, we first show that innate immunity genes have globally...
Topics
- Adaptation, Physiological
- Animals
- Genome-Wide Association Study
- Humans
- Immunity, Innate
- Neanderthals
- Polymorphism, Single Nucleotide
- Selection, Genetic