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Article

Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes.

American journal of human genetics - 7 Jan 2016

Deschamps Matthieu, Laval Guillaume, Fagny Maud, Itan Yuval, Abel Laurent, Casanova Jean-Laurent, Patin Etienne, Quintana-Murci Lluis

Abstract excerpt

Human genes governing innate immunity provide a valuable tool for the study of the selective pressure imposed by microorganisms on host genomes. A comprehensive, genome-wide study of how selective constraints and adaptations have driven the evolution of innate immunity genes is missing. Using full-genome sequence variation from the 1000 Genomes Project, we first show that innate immunity genes have globally...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26748513
DOI: 10.1016/j.ajhg.2015.11.014
PMCID: PMC4716683

Genes

STAT1
TLR1
TLR10
TLR6
TRAF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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