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Article

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense.

PLoS genetics - 1 Jul 2009

Barreiro Luis B, Ben-Ali Meriem, Quach Hélène, Laval Guillaume, Patin Etienne, Pickrell Joseph K, Bouchier Christiane, Tichit Magali, Neyrolles Olivier, Gicquel Brigitte, Kidd Judith R, Kidd Kenneth K, Alcaïs Alexandre, Ragimbeau Josiane, Pellegrini Sandra, Abel Laurent, Casanova Jean-Laurent, Quintana-Murci Lluís

Abstract excerpt

Infectious diseases have been paramount among the threats to health and survival throughout human evolutionary history. Natural selection is therefore expected to act strongly on host defense genes, particularly on innate immunity genes whose products mediate the direct interaction between the ho...

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Source

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Identifiers

PMID: 19609346
DOI: 10.1371/journal.pgen.1000562
PMCID: PMC2702086

Genes

TLR1
TLR10
TLR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19609346-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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