Article

Divergent Effects of <i>APOE3</i> and <i>APOE4</i> Human Astrocytes on Key Alzheimer’s Disease Hallmarks in Chimeric Mice

2025-01-29

Abstract excerpt

<h4>SUMMARY</h4> Despite strong evidence supporting that both astrocytes and apolipoprotein E (APOE) play crucial roles in the pathogenesis and progression of Alzheimer’s disease (AD), the impact of astrocytes carrying different APOE variants on key AD pathological hallmarks remains largely unknown. To explore such effects in a human relevant context, we generated a chimeric model of AD. We transplanted isogenic...

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Literature Corpus work: b99c7df6-771a-5265-a3b0-dff4adbe2526
DOI: 10.1101/2025.01.28.635271

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Divergent Effects of <i>APOE3</i> and <i>APOE4</i> Human Astrocytes on Key Alzheimer’s Disease Hallmarks in Chimeric MiceDOI 10.1101/2025.01.28.635271Read

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