Article

PEBP1 amplifies mitochondrial dysfunction induced integrated stress response

2024-09-23

Abstract excerpt

Mitochondrial dysfunction is involved in numerous diseases and the aging process. The integrated stress response (ISR) serves as a critical adaptation mechanism to a variety of stresses, including those originating from mitochondria. By utilizing thermal proteome profiling (TPP), we uncovered that phosphatidylethanolamine-binding protein 1 (PEBP1), also known as Raf kinase inhibitory protein (RKIP), is thermally s...

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Literature Corpus work: eafdcc98-37fd-5af3-a289-b96576e99b4b
DOI: 10.1101/2024.09.20.614039

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