Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated Stress Response (ISR) Pathway: Unraveling Its Role in Cellular Senescence

13 Dec 2023

Abstract excerpt

Cellular senescence is a complex process characterized by irreversible cell cycle arrest. Senescent cells accumulate with age, promoting disease development, yet the absence of specific markers hampers the development of selective anti-senescence drugs. The integrated stress response (ISR), an evolutionarily highly conserved signaling network activated in response to stress, globally downregulates protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to RNA regulation and disease
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38139251
DOI: 10.3390/ijms242417423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated Stress Response (ISR) Pathway: Unraveling Its Role in Cellular SenescencePMID 38139251Read ↗

The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevitySemantic proximity Read ↗

Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype.Semantic proximity Read ↗

Senescence suppresses the integrated stress response and activates a stress-enhanced secretory phenotypeSemantic proximity Read ↗

The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease.Semantic proximity Read ↗

A Unique ISR Program Determines Cellular Responses to Chronic Stress.Semantic proximity Read ↗

Unfolded proteins in the mitochondria activate HRI and shut-down of mitochondrial protein translationSemantic proximity Read ↗

Cellular proteostasis decline in human senescenceSemantic proximity Read ↗

Cellular proteostasis decline in human senescenceSemantic proximity Read ↗

ATM-associated signalling triggers the unfolded protein response and cell death in response to stressSemantic proximity Read ↗

Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast CancersSemantic proximity Read ↗

Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and DiseaseSemantic proximity Read ↗

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.