Article

Inositol-Requiring Enzyme 1 pathway and autophagy drive sequential response of endothelial cells to febrile range hyperthermia

2024-11-24

Abstract excerpt

<h4>Context</h4> Fever is an evolutionarily conserved and adaptive response during infections. However, prolonged fever has numerous systemic metabolic and functional side effects. In the heart, prolonged fever associated with infection is linked to fatal adverse effects, particularly involving impaired coronary circulation. Yet, the direct relationship between elevated temperature and coronary microcirculation d...

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Literature Corpus work: 41748a52-0fbb-5e44-8a8d-6bb8deb3b658
DOI: 10.1101/2024.11.22.624904

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