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DNA Strand Break Repair and Human Genetic Disease

1 Sept 2007

Abstract excerpt

Each day tens of thousands of DNA single-strand breaks (SSBs) arise in every cell from the attack of deoxyribose and DNA bases by reactive oxygen species and other electrophilic molecules. DNA double-strand breaks (DSBs) also arise, albeit at a much lower frequency, from similar attacks and from the encounter of unrepaired SSBs and possibly other DNA structures by DNA replication forks. DSBs are also created...

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PMID: 17887919
DOI: 10.1146/annurev.genom.7.080505.115648

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