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A Compensatory RNase E Variation Increases Iron Piracy and Virulence in Multidrug-Resistant <i>Pseudomonas aeruginosa</i> during Macrophage Infection

2022-10-24

Abstract excerpt

During chronic cystic fibrosis (CF) infections, evolved Pseudomonas aeruginosa antibiotic resistance is linked to increased pulmonary exacerbations, decreased lung function, and hospitalizations. However, the virulence mechanisms underlying worse outcomes caused by antibiotic resistant infections are poorly understood. Here, we investigated evolved aztreonam resistant P. aeruginosa virulence mechanisms. Using a...

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Literature Corpus work
eac94e6e-6f69-5ffe-92fc-3313e35d380b
DOI
10.1101/2022.10.24.513460
Open publication

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A Compensatory RNase E Variation Increases Iron Piracy and Virulence in Multidrug-Resistant <i>Pseudomonas aeruginosa</i> during Macrophage InfectionDOI 10.1101/2022.10.24.513460
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