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Ferroptosis and iron-based therapies in Pseudomonas aeruginosa infections: From pathogenesis to treatment

5 Sept 2025

Abstract excerpt

Pseudomonas aeruginosa is a globally prevalent multidrug-resistant pathogen that causes severe infections, particularly in immunocompromised individuals. This review focuses on the dual role of iron in P. aeruginosa infections: as a critical nutrient for bacterial growth and as a mediator of host cell ferroptosis, a form of iron-dependent cell death. We summarize how P. aeruginosa manipulates iron metabolism to...

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PMID: 40911411
DOI: 10.1080/21505594.2025.2553787

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