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<i>Pseudomonas aeruginosa lasR</i> Mutants Resist Phagocytosis and Alter Inflammatory Cytokine Production by Cystic Fibrosis Macrophages

2025-09-25

Abstract excerpt

Cystic Fibrosis is characterized by chronic muco-obstructive lung disease and infection. People with CF (pwCF) are often colonized with Pseudomonas aeruginosa for years to decades, allowing for evolutionary adaptation. In chronic P. aeruginosa lung isolates from pwCF, the quorum sensing regulator LasR frequently is nonfunctional, however the factors enabling lasR loss-of-function (LOF) mutant selection are inco...

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Literature Corpus work
a0028982-5eca-5cfe-8030-80ca287fa237
DOI
10.1101/2025.09.25.678585
Open publication

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<i>Pseudomonas aeruginosa lasR</i> Mutants Resist Phagocytosis and Alter Inflammatory Cytokine Production by Cystic Fibrosis MacrophagesDOI 10.1101/2025.09.25.678585
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