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Genome-wide CRISPRi-seq identified ferredoxin-NADP reductase FprB as a synergistic target for gallium therapy in <i>Pseudomonas aeruginosa</i>

2024-09-01

Abstract excerpt

With the rise of antibiotic-resistant bacteria, non-antibiotic therapies like gallium are increasingly gaining attention. Gallium ions exhibit potent activity against multidrug-resistant bacteria and intravenous gallium nitrite is under phase 2 clinical trials to treat chronic Pseudomonas aeruginosa infections in cystic fibrosis patients. However, its clinical efficacy is constrained by the achievable peak concen...

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Literature Corpus work
9c19bea5-1520-56c8-bb25-5007398e0b53
DOI
10.1101/2024.09.01.610675
Open publication

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Genome-wide CRISPRi-seq identified ferredoxin-NADP reductase FprB as a synergistic target for gallium therapy in <i>Pseudomonas aeruginosa</i>DOI 10.1101/2024.09.01.610675
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