Article

Genome-wide CRISPRi-seq identified ferredoxin-NADP reductase FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosa

2024-10-07

Abstract excerpt

<title>Abstract</title> With the rise of antibiotic-resistant bacteria, non-antibiotic therapies like gallium are increasingly gaining attention. Gallium ions exhibit potent activity against multidrug-resistant bacteria and intravenous gallium nitrite is under phase 2 clinical trials to treat chronic Pseudomonas aeruginosa infections in cystic fibrosis patients. However, its clinical efficacy is constrained by...

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Literature Corpus work: f9a8714b-9cca-5797-a8ee-baf74b838d15
DOI: 10.21203/rs.3.rs-5011900/v1

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