Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivo.

Nature communications - 25 Sept 2025

Fernandes Sheryl E, Ortega Humberto, Vaillancourt Mylene, Galdino Anna Clara M, Stotland Aleksandr, Mun Kyu Shik, Aguilar Diane, Doi Yohei, Lee Janet S, Burgener Elizabeth B, Barrick Jeffrey E, Schertzer Jeffrey W, Jorth Peter

Abstract excerpt

Antibiotic resistance is a threat to human health, yet recent work highlights how loss of resistance may drive pathogenesis in some bacteria. In two recent studies, we found that β-lactam antibiotics and nutrient stresses faced during infection selected for genetic inactivation of the Pseudomonas aeruginosa antibiotic efflux pump mexEFoprN. Unexpectedly, efflux pump mutations increased P. aeruginosa virulence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystic Fibrosis
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycolipids

Share to Membrane Transport Proteins

Share to Pancreatic Elastase

Share to Pseudomonas aeruginosa

Share to Pseudomonas Infections

Share to Quorum Sensing

Source

Open in PubMed Open full text

Identifiers

PMID: 40998772
DOI: 10.1038/s41467-025-63284-7
PMCID: PMC12462495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivo.PMID 40998772Read ↗

Evolutionary loss of an antibiotic efflux pump increases Pseudomonas aeruginosa quorum sensing mediated virulence in vivoSemantic proximity Read ↗

The rapid in vivo evolution of Pseudomonas aeruginosa in ventilator-associated pneumonia patients leads to attenuated virulence.Semantic proximity Read ↗

Adaptive Evolution of Pseudomonas aeruginosa in Human Airways Shows Phenotypic Convergence Despite Diverse Patterns of Genomic Changes.Semantic proximity Read ↗

<i>Achromobacter</i> genetic adaptation in cystic fibrosisSemantic proximity Read ↗

A large-scale comparison shows that genetic changes causing antibiotic resistance in experimentally evolved <i>Pseudomonas aeruginosa</i> predict those in naturally evolved bacteriaSemantic proximity Read ↗

Systems-level analysis of NalD mutation, a recurrent driver of rapid drug resistance in acute Pseudomonas aeruginosa infectionSemantic proximity Read ↗

Evolutionary genomics of epidemic and nonepidemic strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

Pathogenicity of nosocomial Pseudomonas aeruginosa analyzed by pan-genomicsSemantic proximity Read ↗

Plasticity in a bacterial global regulatory switch that drives a shift in antibiotic resistance and virulenceSemantic proximity Read ↗

Pseudomonas aeruginosa infection and persistence mechanisms in cystic fibrosis patientsSemantic proximity Read ↗

Non-interchangeable functions of efflux transporters of Pseudomonas aeruginosa in survival under infection-associated stressSemantic proximity Read ↗

The neglected intrinsic resistome of bacterial pathogens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.