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Article

In Vivo Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix

2019-12-05

Abstract excerpt

<h4>Background</h4> Protease Inhibitors (PIs) are the second- and last-line therapy for the majority of HIV-infected patients worldwide. Only around 20% of individuals who fail PI regimens develop major resistance mutations in protease. We sought to explore the role of mutations in gag-protease genotypic and phenotypic changes within six Nigerian patients who failed PI-based regimens without known drug resistanc...

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Literature Corpus work
eaa39829-3850-57b0-a254-6f0e6fc87c3e
DOI
10.1101/865840
Open publication

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In Vivo Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 MatrixDOI 10.1101/865840
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