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Article

Navigating HIV-1 drug resistance: A comprehensive review of protease inhibitor efficacy and mutation dynamics.

Drug discovery today - 1 Jul 2026

Yang Kaile, Sun Xiurong, Chen Junbing, Liu Zhijun, Chen Zhe-Sheng

Abstract excerpt

HIV type 1 (HIV-1) poses a significant threat to global public health. Protease, a critical enzyme in the HIV-1 life cycle, has long been regarded as an important therapeutic target. However, the emergence of drug resistance mutations enables HIV-1 to evade the inhibitory effects mediated by protease inhibitors (PIs), thereby compromising the long-term efficacy of antiretroviral therapy. This review analyzes the...

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Identifiers

PMID: 42217819
DOI: 10.1016/j.drudis.2026.104711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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