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Gag-Protease Sequence Evolution Following Protease Inhibitor Monotherapy Treatment Failure in HIV-1 Viruses Circulating in East Africa.

AIDS research and human retroviruses - 1 Oct 2015

Sutherland Katherine A, Goodall Ruth L, McCormick Adele, Kapaata Anne, Lyagoba Fred, Kaleebu Pontiano, Thiltgen Geant, Gilks Charles F, Spyer Moira, Kityo Cissy, Pillay Deenan, Dunn David, Gupta Ravindra K

Abstract excerpt

Around 2.5 million HIV-infected individuals failing first-line therapy qualify for boosted protease inhibitor (bPI)-based second-line therapy globally. Major resistance mutations are rarely present at treatment failure in patients receiving bPI and the determinants of failure in these patients remain unknown. There is evidence that Gag can impact PI susceptibility. Here, we have sequenced Gag-Protease before and...

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Identifiers

PMID: 26258548
DOI: 10.1089/aid.2015.0138
PMCID: PMC4675176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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