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Article

In Vivo Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix.

mBio - 3 Nov 2020

Datir Rawlings, Kemp Steven, El Bouzidi Kate, Mlchocova Petra, Goldstein Richard, Breuer Judy, Towers Greg J, Jolly Clare, Quiñones-Mateu Miguel E, Dakum Patrick S, Ndembi Nicaise, Gupta Ravindra K

Abstract excerpt

Protease inhibitors (PIs) are the second- and last-line therapy for the majority of HIV-infected patients worldwide. Only around 20% of individuals who fail PI regimens develop major resistance mutations in protease. We sought to explore the role of mutations in gag-pro genotypic and phenotypic changes in viruses from six Nigerian patients who failed PI-based regimens without known drug resistance-associated...

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Share to Dose-Response Relationship, Drug
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

Share to Genome, Viral

Share to HIV Antigens

Share to Protease Inhibitors

Share to Sequence Deletion

Share to Viral Load

Source

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Identifiers

PMID: 33144375
DOI: 10.1128/mBio.02036-20
PMCID: PMC7642677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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