Article
Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial.
PloS one - 1 Jan 2015
Sutherland Katherine A, Parry Chris M, McCormick Adele, Kapaata Anne, Lyagoba Fred, Kaleebu Pontiano, Gilks Charles F, Goodall Ruth, Spyer Moira, Kityo Cissy, Pillay Deenan, Gupta Ravindra K
Abstract excerpt
BACKGROUND: Major protease mutations are rarely observed following failure with protease inhibitors (PI), and other viral determinants of failure to PI are poorly understood. We therefore characterized Gag-Protease phenotypic susceptibility in subtype A and D viruses circulating in East Africa following viral rebound on PIs. METHODS: Samples from baseline and treatment failure in patients enrolled in the second...
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