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Article

Homing gene drives can transfer rapidly between Anopheles gambiae strains with minimal carryover of flanking sequences.

Nature communications - 10 Aug 2024

Pescod Poppy, Bevivino Giulia, Anthousi Amalia, Shepherd Josephine, Shelton Ruth, Lombardo Fabrizio, Nolan Tony

Abstract excerpt

CRISPR-Cas9 homing gene drives are designed to induce a targeted double-stranded DNA break at a wild type allele ('recipient'), which, when repaired by the host cell, is converted to the drive allele from the homologous ('donor') chromosome. Germline localisation of this process leads to super-Mendelian inheritance of the drive and the rapid spread of linked traits, offering a novel strategy for population...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39122734
DOI: 10.1038/s41467-024-51225-9
PMCID: PMC11315913

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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