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Article

Integrating multiplexing into confineable gene drives effectively overrides resistance in Anopheles stephensi.

Nature communications - 7 May 2026

Larrosa-Godall Mireia, Shackleford Lewis, Edgington Matthew P, Leftwich Philip T, Luk James C Y, Southworth Joshua, Rosell Stewart, Creasey Jake T, Aked Jack M, Nevard Katherine, Dodds Alexander, Mckee Morgan, Adedeji Eunice, Gonzalez Estela, Ang Joshua X D, Anderson Michelle A E, Alphey Luke

Abstract excerpt

Anopheles stephensi is a major malaria vector mainly present in southern Asia and the Arabian Peninsula. Since 2012 it has invaded several countries of eastern Africa, stimulating urgent efforts to develop more efficient strategies for vector control such as CRISPR/Cas9-based homing gene drives. Target site resistance due to end-joining repair is a significant challenge to the deployment of these systems. The use...

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Identifiers

PMID: 42115602
DOI: 10.1038/s41467-026-72835-5
PMCID: PMC13388953

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