Article

Uncovering the regulatory landscape of early human B-cell lymphopoiesis and its implications in the pathogenesis of B-cell acute lymphoblastic leukemia

2023-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulation of the early stages of B-cell lymphopoiesis, orchestrating the development of cellular immunity, may induce malignant transformations. Therefore, it is essential to characterize the gene regulatory network (GRN) driving B-cell lymphopoiesis in healthy individuals to uncover malignancy mechanisms. To this end, we generated a dataset that included paired human data for chromatin acce...

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Literature Corpus work: fa5aac83-af92-55e5-9c2c-8f3bde13bc25
DOI: 10.1101/2023.07.01.547234

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