Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities.

doi:10.1186/s13073-020-00799-2

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Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities.

Genome medicine - 20 Nov 2020

Mehtonen Juha, Teppo Susanna, Lahnalampi Mari, Kokko Aleksi, Kaukonen Riina, Oksa Laura, Bouvy-Liivrand Maria, Malyukova Alena, Mäkinen Artturi, Laukkanen Saara, Mäkinen Petri I, Rounioja Samuli, Ruusuvuori Pekka, Sangfelt Olle, Lund Riikka, Lönnberg Tapio, Lohi Olli, Heinäniemi Merja

Abstract excerpt

BACKGROUND: Tight regulatory loops orchestrate commitment to B cell fate within bone marrow. Genetic lesions in this gene regulatory network underlie the emergence of the most common childhood cancer, acute lymphoblastic leukemia (ALL). The initial genetic hits, including the common translocation that fuses ETV6 and RUNX1 genes, lead to arrested cell differentiation. Here, we aimed to characterize transcription...

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PMID: 33218352
DOI: 10.1186/s13073-020-00799-2
PMCID: PMC7679990

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