Article

Defining the BTK-dependent chromatin-informed gene regulatory network in chronic lymphocytic leukemia

2026-05-15

Abstract excerpt

<title>Abstract</title> <p>Bruton tyrosine kinase (BTK) is central to chronic lymphocytic leukemia (CLL) biology, yet the regulatory programs that depend on BTK remain poorly defined. Here, we used acute NX-5948 (Bexobrutideg)-mediated BTK degradation to define BTK-dependent regulatory circuitry in CLL. Integrating early transcriptional and chromatin responses with chromatin-state annotation, target-gene linkage,...

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Literature Corpus work: 049160d1-1a44-5e95-a621-901a3bcec23c
DOI: 10.21203/rs.3.rs-9485118/v1

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