Article

Structural basis of a public antibody response to SARS-CoV-2

2020-06-09

Abstract excerpt

<h4>ABSTRACT</h4> Molecular-level understanding of human neutralizing antibody responses to SARS-CoV-2 could accelerate vaccine design and facilitate drug discovery. We analyzed 294 SARS-CoV-2 antibodies and found that IGHV3-53 is the most frequently used IGHV gene for targeting the receptor binding domain (RBD) of the spike (S) protein. We determined crystal structures of two IGHV3-53 neutralizing antibodies +/-...

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Literature Corpus work: ea97ebda-4cf9-5ff3-af98-7ac19b16c7e6
DOI: 10.1101/2020.06.08.141267

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