Article

An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain

2020-07-27

Abstract excerpt

<h4>ABSTRACT</h4> IGHV3-53-encoded neutralizing antibodies are commonly elicited during SARS-CoV-2 infection and target the receptor-binding domain (RBD) of the spike (S) protein. Such IGHV3-53 antibodies generally have a short CDR H3 due to structural constraints in binding the RBD (mode A). However, a small subset of IGHV3-53 antibodies to the RBD contain a longer CDR H3. Crystal structures of two IGHV3-53 neut...

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Literature Corpus work: 73b8b1f6-68e7-50f7-8c86-ac5e02a6f9f5
DOI: 10.1101/2020.07.26.222232

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