Article

Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

2020-05-29

Abstract excerpt

<h4>Summary</h4> Neutralizing antibody responses to coronaviruses focus on the trimeric spike, with most against the receptor-binding domain (RBD). Here we characterized polyclonal IgGs and Fabs from COVID-19 convalescent individuals for recognition of coronavirus spikes. Plasma IgGs differed in their degree of focus on RBD epitopes, recognition of SARS-CoV, MERS-CoV, and mild coronaviruses, and how avidity effec...

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Identifiers and source

Literature Corpus work: f307c9cf-aa11-5395-b117-783a6d18c904
DOI: 10.1101/2020.05.28.121533

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