Article

Paired heavy and light chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses

2021-01-03

Abstract excerpt

<h4>Summary</h4> Understanding protective mechanisms of antibody recognition can inform vaccine and therapeutic strategies against SARS-CoV-2. We discovered a new antibody, 910-30, that targets the SARS-CoV-2 ACE2 receptor binding site as a member of a public antibody response encoded by IGHV3-53/IGHV3-66 genes. We performed sequence and structural analyses to explore how antibody features correlate with SARS-CoV...

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Literature Corpus work: ef7cbe75-725a-591e-805f-de580c537c03
DOI: 10.1101/2020.12.31.424987

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