Article

Paired Heavy and Light Chain Signatures Contribute to Potent SARS-CoV-2 Neutralization in Public Antibody Responses

2020-12-23

Abstract excerpt

Understanding protective mechanisms of antibody recognition can inform vaccine and therapeutic strategies against SARS-CoV-2. We discovered a new antibody, 910-30, that targets the SARS-CoV-2 ACE2 receptor binding site as a member of a public antibody response encoded by IGHV3-53/IGHV3-66 genes. We performed sequence and structural analyses to explore how IGHV3-53/IGHV3-66 antibody features correlate with SARS-CoV...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c88551a1-2c65-5b3f-9da6-41fcf426bd72
DOI: 10.2139/ssrn.3754549

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Paired Heavy and Light Chain Signatures Contribute to Potent SARS-CoV-2 Neutralization in Public Antibody ResponsesDOI 10.2139/ssrn.3754549Read

Paired heavy and light chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responsesSemantic proximity Read

Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responsesSemantic proximity Read

Structural basis of a public antibody response to SARS-CoV-2Semantic proximity Read

Deep immunoglobulin repertoire sequencing depicts a comprehensive atlas of spike-specific antibody lineages shared among COVID-19 convalescentsSemantic proximity Read

Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variantsSemantic proximity Read

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2Semantic proximity Read

Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2Semantic proximity Read

One Thousand SARS-CoV-2 Antibody Structures Reveal Convergent Binding and Near-Universal Immune EscapeSemantic proximity Read

Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domainSemantic proximity Read

Convergent IGHV3-53/3-66 antibodies elicited by Omicron BA.1 infection broadly neutralize emerging SARS-CoV-2 variantsSemantic proximity Read

Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2Semantic proximity Read

Light chain of a public SARS-CoV-2 class-3 antibody modulates neutralization against OmicronSemantic proximity Read