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Article

Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain

21 Jun 2021

Abstract excerpt

Since the COVID-19 pandemic onset, the antibody response to SARS-CoV-2 has been extensively characterized. Antibodies to the receptor binding domain (RBD) on the spike protein are frequently encoded by IGHV3-53/3-66 with a short complementarity-determining region (CDR) H3. Germline-encoded sequence motifs in heavy chain CDRs H1 and H2 have a major function, but whether any common motifs are present in CDR H3,...

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PMID: 34155209
DOI: 10.1038/s41467-021-24123-7

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