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Article

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.

Nature - 1 Dec 2020

Barnes Christopher O, Jette Claudia A, Abernathy Morgan E, Dam Kim-Marie A, Esswein Shannon R, Gristick Harry B, Malyutin Andrey G, Sharaf Naima G, Huey-Tubman Kathryn E, Lee Yu E, Robbiani Davide F, Nussenzweig Michel C, West Anthony P, Bjorkman Pamela J

Abstract excerpt

The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein1-5 show promise therapeutically and are being evaluated clinically6-8. Here, to identify the structural correlates of SARS-CoV-2 neutralization, we solved eight new...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33045718
DOI: 10.1038/s41586-020-2852-1
PMCID: PMC8092461

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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