Article

Structural and mutational analyses define distinct molecular routes to broad SARS-CoV-2 receptor-binding domain recognition

2026-08-18

Abstract excerpt

<h4>ABSTRACT</h4> Broadly reactive antibodies elicited by SARS-CoV-2 infection or vaccination can reveal conserved viral vulnerabilities and inform vaccines with broad coronavirus coverage. Here, we characterize two human-derived monoclonal antibodies, B2014 and C5078, that recognize conserved epitopes on the SARS-CoV-2 RBD and retain activity across antigenically distinct variants. Notably, C5078 also recognizes...

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Literature Corpus work: a9c69ead-f6a4-52d8-bde8-7915383f998a
DOI: 10.64898/2026.08.17.745277

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