Article

Exploration of Mechanisms of Drug Resistance in a Microfluidic Device and Patient Tissues

2022-11-16

Abstract excerpt

Chemoresistance is a major cause of treatment failure in many cancers. However, the life cycle of cancer cells as they respond to and survive environmental and therapeutic stress is understudied. In this study, we utilized a microfluidic device to induce the development of doxorubicin-resistant (DOXR) cells from triple negative breast cancer (TNBC) cells within 11 days by generating gradients of DOX and medium. I...

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Literature Corpus work: ea83f4c9-dcab-52d0-a764-789de4388de2
DOI: 10.1101/2022.11.14.515727

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