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Exploration of drug resistance mechanisms in triple negative breast cancer cells using a microfluidic device and patient tissues

3 Oct 2023

Abstract excerpt

Chemoresistance is a major cause of treatment failure in many cancers. However, the life cycle of cancer cells as they respond to and survive environmental and therapeutic stress is understudied. In this study, we utilized a microfluidic device to induce the development of doxorubicin-resistant (DOXR) cells from triple negative breast cancer (TNBC) cells within 11 days by generating gradients of DOX and medium....

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PMID: 38536720
DOI: 10.7554/elife.88830

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