Article

Hypoxic-Core (HyCo) Spheroids Recapitulate Hallmarks of Clinical Hypoxia: A Simple Chip-Based Method for Translational Oncology

2025-04-09

Abstract excerpt

Hypoxia influences the biology and response of cancers. No user-friendly device allows the study of hypoxia on highly-controlled clinically-relevant tumor models. Here, we describe how hypoxic-core (HyCo) spheroids generated using our unique non-perfused microfluidic device recapitulate key clinical hallmarks of hypoxia in vitro . Our PDMS-made system can generate up to 240 spheroids naturally exhibiting a diffus...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6b9c1748-8eb5-5c0c-af00-8712e01c0cdc
DOI: 10.1101/2025.04.03.647075

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypoxic-Core (HyCo) Spheroids Recapitulate Hallmarks of Clinical Hypoxia: A Simple Chip-Based Method for Translational OncologyDOI 10.1101/2025.04.03.647075Read

Investigating the impact of the interstitial fluid flow and hypoxia interface on cancer biology using a spheroid-on-chip perfusion systemSemantic proximity Read

Patient-derived esophageal adenocarcinoma organ chip: a physiologically relevant platform for functional precision oncologySemantic proximity Read

Breaking the mold: 3D cell cultures reshaping the future of cancer researchSemantic proximity Read

A microfluidic model to recapitulate pH and oxygen gradients in solid tumorsSemantic proximity Read

Microphysiological vascularized solid tumor model for drugs and cell therapies screeningSemantic proximity Read

A 3D microtumour system that faithfully represents ovarian cancer minimal residual diseaseSemantic proximity Read

The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid TumorsSemantic proximity Read

Tumoroid-on-a-Plate (ToP): Physiologically Relevant Cancer Model Generation and Therapeutic ScreeningSemantic proximity Read

Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptationsSemantic proximity Read

Microfluidic modelling of the tumor microenvironment for anti-cancer drug developmentSemantic proximity Read

Tumor Spheroids Layered in an Imageable Cancer Environment (T-SLICE): a novel <i>in vitro</i> platform to study tumor biologySemantic proximity Read

Microfluidic Platform for Drug Response Profiling in NSCLC Patient-Derived OrganoidsSemantic proximity Read