Article
Genetic and phenotypic profiling of single living circulating tumor cells from patients with microfluidics.
Proceedings of the National Academy of Sciences of the United States of America - 7 May 2024
Dong Zaizai, Wang Yusen, Xu Gaolian, Liu Bing, Wang Yang, Reboud Julien, Jajesniak Pawel, Yan Shi, Ma Pingchuan, Liu Feng, Zhou Yuhao, Jin Zhiyuan, Yang Kuan, Huang Zhaocun, Zhuo Minglei, Jia Bo, Fang Jian, Zhang Panpan, Wu Nan, Yang Mingzhu, Cooper Jonathan M, Chang Lingqian
Abstract excerpt
Accurate prediction of the efficacy of immunotherapy for cancer patients through the characterization of both genetic and phenotypic heterogeneity in individual patient cells holds great promise in informing targeted treatments, and ultimately in improving care pathways and clinical outcomes. Here, we describe the nanoplatform for interrogating living cell host-gene and (micro-)environment (NICHE) relationships,...
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