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Single-cell RNA-sequencing of migratory breast cancer cells: discovering genes associated with cancer metastasis

1 Jan 2019

Abstract excerpt

Considerable evidence suggests breast cancer metastasis arises from cells undergoing epithelial-to-mesenchymal-transition (EMT) and cancer stem-like cells (CSCs). Using a microfluidic device that enriches migratory breast cancer cells with enhanced capacity for tumor formation and metastasis, we identified genes differentially expressed in migratory cells by high-throughput single-cell RNA-sequencing. Migratory...

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PMID: 31710321
DOI: 10.1039/c9an01358j

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