Article
Multiple single cell screening and DNA MDA amplification chip for oncogenic mutation profiling.
Lab on a chip - 27 Feb 2018
Li Ren, Zhou Mingxing, Yue Chunyan, Zhang Weikai, Ma Yan, Peng Hailin, Hu Zhiyuan, Wei Zewen
Abstract excerpt
The oncogenic mutation heterogeneity of the cancer cell population has been proven to be essential for predicting both drug-response and drug-resistance of targeted therapies, such as tyrosine kinase inhibitors. It is necessary to accurately evaluate the mutation heterogeneity, oncogenic mutation and resistant mutation profiling at a single cell level. However, there are two major hurdles in the process. First,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.