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Article

Rapid emergence and mechanisms of resistance by U87 glioblastoma cells to doxorubicin in an in vitro tumor microfluidic ecology.

Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2016

Han Jeonghun, Jun Yukyung, Kim So Hyun, Hoang Hong-Hoa, Jung Yeonjoo, Kim Suyeon, Kim Jaesang, Austin Robert H, Lee Sanghyuk, Park Sungsu

Abstract excerpt

In vitro prediction of the probable rapid emergence of resistance to a drug in tumors could act to winnow out potential candidates for further costly development. We have developed a microfluidic device consisting of ∼500 hexagonal microcompartments that provides a complex ecology with wide ranges of drug and nutrient gradients and local populations. This ecology of a fragmented metapopulation induced the drug...

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Identifiers

PMID: 27911816
DOI: 10.1073/pnas.1614898113
PMCID: PMC5167174

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CARD6
NLRP13
NSD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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