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Article

Phenotypic drug profiling in droplet microfluidics for better targeting of drug-resistant tumors.

Lab on a chip - 7 Dec 2015

Sarkar S, Cohen N, Sabhachandani P, Konry T

Abstract excerpt

Acquired drug resistance is a key factor in the failure of chemotherapy. Due to intratumoral heterogeneity, cancer cells depict variations in intracellular drug uptake and efflux at the single cell level, which may not be detectable in bulk assays. In this study we present a droplet microfluidics-based approach to assess the dynamics of drug uptake, efflux and cytotoxicity in drug-sensitive and drug-resistant...

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Identifiers

PMID: 26456240
DOI: 10.1039/c5lc00923e
PMCID: PMC4666301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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