Article

Shared Genomic Architecture Between Schizophrenia and Multiple Sclerosis Identifies an Un-Drugged HCAR1 Neuroimmune Checkpoint

2026-07-05

Abstract excerpt

Multiple Sclerosis (MS) pathogenesis is contingent upon the hyper-proliferative infiltration of peripheral macrophages across the blood-brain barrier. While front-line therapeutics, such as Dimethyl Fumarate, achieve clinical efficacy by agonizing the HCAR2 immune cooling switch, the tandemly duplicated HCAR1 lactate sensor has remained entirely unexplored. Here, by cross-referencing MS and Schizophrenia (SCZ) g...

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Literature Corpus work: ea7aad02-bdf9-5a64-989f-bfdd0ba3cc42
DOI: 10.64898/2026.06.30.735650

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