Article
Mapping the immune-genetic architecture of Epstein-Barr virus-related phenotypes and multiple sclerosis through a single-cell genetic framework for target prioritization and pharmacologic hypothesis generation.
Multiple sclerosis and related disorders - 1 Oct 2026
Zhou Yixiang, Huang Xindi, She Xiao, Hao Qin, Mi Zhikuan, Yang Yanling
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is a severe neuroinflammatory disease causing substantial long-term disability. Strong epidemiologic evidence links Epstein-Barr virus (EBV) exposure with MS risk, but genetic evidence for immune target prioritization in EBV-related phenotypes remains limited. METHODS: We integrated single-cell cis-eQTL data from 14 immune cell types with GWASs of an EBV-related clinical...
Read the complete abstract on PubMedTopics
- Humans
- Multiple Sclerosis
- Phenotype
- Epstein-Barr Virus Infections
- Genome-Wide Association Study