Article

An integrated single-cell transcriptomic pipeline identifies ZNF740/BRD3 and Cathepsin S as novel therapeutic targets in chronic active rim smoldering multiple sclerosis

2026-06-03

Abstract excerpt

<title>Abstract</title> <p>Background. Smoldering multiple sclerosis (MS), characterised by slowly expanding chronic active rim (CA-RIM) lesions, is responsible for a substantial proportion of ir- reversible disability yet has no approved disease-modifying therapy. The molecular drivers of the CA-RIM lesion microenvironment are poorly characterised. Methods. We developed a four-phase computational pipeline integr...

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Literature Corpus work: 39f0dc23-b389-5155-ad57-532626958df5
DOI: 10.21203/rs.3.rs-9890742/v1

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