Article

An integrated single-cell transcriptomic pipeline identifies ZNF740/BRD3 and Cathepsin S as novel therapeutic targets in chronic active rim smoldering multiple sclerosis

2026-07-08

Abstract excerpt

<title>Abstract</title> <p>Background. Smoldering multiple sclerosis (MS), characterised by slowly expanding chronic active rim (CA-RIM) lesions, is responsible for a substantial proportion of irreversible disability yet has no approved disease-modifying therapy. The molecular drivers of the CA-RIM lesion microenvironment are poorly characterised. Methods. We developed a four-phase computational pipeline integra...

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Literature Corpus work: 4f90ba1c-34bc-518c-96e7-15884b20345b
DOI: 10.21203/rs.3.rs-9890742/v2

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