A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis.

doi:10.1038/s41467-024-50794-z

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Article

A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis.

Nature communications - 30 Jul 2024

Pahlevan Kakhki Majid, Giordano Antonino, Starvaggi Cucuzza Chiara, Venkata S Badam Tejaswi, Samudyata Samudyata, Lemée Marianne Victoria, Stridh Pernilla, Gkogka Asimenia, Shchetynsky Klementy, Harroud Adil, Gyllenberg Alexandra, Liu Yun, Boddul Sanjaykumar, James Tojo, Sorosina Melissa, Filippi Massimo, Esposito Federica, Wermeling Fredrik, Gustafsson Mika, Casaccia Patrizia, Hillert Jan, Olsson Tomas, Kockum Ingrid, Sellgren Carl M, Golzio Christelle, Kular Lara, Jagodic Maja

Abstract excerpt

Multiple Sclerosis (MS) is a heterogeneous inflammatory and neurodegenerative disease with an unpredictable course towards progressive disability. Treating progressive MS is challenging due to limited insights into the underlying mechanisms. We examined the molecular changes associated with primary progressive MS (PPMS) using a cross-tissue (blood and post-mortem brain) and multilayered data (genetic, epigenetic,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39079955
DOI: 10.1038/s41467-024-50794-z
PMCID: PMC11289459

Genes

CHD1L
PRKAB2

Provenance

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