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Pharmacological Antagonism of Kainate Receptor Rescues Dysfunction and Loss of Dopamine Neurons in a Mouse Model of Human Parkin-induced Toxicity

2020-06-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Mutations in the <italic>PARK2</italic> gene encoding the protein parkin cause autosomal recessive juvenile parkinsonism (ARJP), a neurodegenerative disease characterized by dysfunction and death of dopamine (DA) neurons in the substantia nigra pars compacta. Since a neuroprotective therapy for ARJP does not exist, research efforts aimed at discovering potential t...

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Literature Corpus work: ea7a7e9d-1fbf-5713-a809-338a3fa6c6bd
DOI: 10.21203/rs.3.rs-36149/v1

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