Article

Dopamine neuron dysfunction and loss in the <i>Prkn</i> R275W mouse model of Juvenile Parkinsonism

2023-09-27

Abstract excerpt

Mutations in the PRKN gene encoding the protein PARKIN cause Autosomal Recessive Juvenile Parkinsonism (ARJP). Harnessing this mutation to create an early-onset Parkinson’s disease (PD) mouse model would provide a unique opportunity to clarify the mechanisms involved in the neurodegenerative process and lay the groundwork for the development of neuroprotective strategies. We created a knock-in mouse carrying the...

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Literature Corpus work: a9e71e19-fa70-59da-9648-aed37e3cb876
DOI: 10.1101/2023.09.26.559326

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