Article

Parkinson’s disease-linked Parkin mutations impair glutamatergic synaptic transmission and plasticity

2018-07-20

Abstract excerpt

Parkinson’s disease (PD)-associated E3 ubiquitin ligase Parkin is enriched at glutamatergic synapses, where it ubiquitinates multiple substrates, suggesting that its mutation/loss-of-function could contribute to the etiology of PD by disrupting excitatory neurotransmission. Here, we evaluate the impact of four common PD-associated Parkin point mutations (T240M, R275W, R334C, G430D) on glutamatergic synaptic functi...

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Literature Corpus work: 3b10246f-c828-5964-9dda-a5920bb25ede
DOI: 10.1101/373597

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